What is the treatment of choice for Kawasaki disease to reduce coronary abnormalities?

• A. IVIG and high-dose aspirin
• B. Antibiotics
• C. Corticosteroids alone
• D. Anticoagulation therapy

Answer: (A)

Prompt IVIG therapy with high-dose aspirin is the treatment of choice to reduce coronary abnormalities in Kawasaki disease. IVIG rapidly modulates the immune-driven vasculitis, lowering inflammation in the coronary arteries and markedly reducing the risk of coronary aneurysms when given within the first 10 days of symptom onset. Accompanying this, high-dose aspirin provides potent anti-inflammatory relief during the acute phase and, once the patient stabilizes, is continued at a low dose to maintain antiplatelet protection against thrombosis in any developing or existing aneurysms. Antibiotics don’t address the vasculitis itself. Corticosteroids alone aren’t proven to prevent coronary complications (though they’re used in IVIG-resistant or certain high-risk cases). Anticoagulation is reserved for specific large aneurysms or thrombosis risk, not the initial standard therapy.