Koplik spots are pathognomonic for measles. True or False?

• A. True
• B. False
• C. Not applicable
• D. Not sure

Answer: (A)

Koplik spots are a classic, highly specific clue for measles. They are tiny bluish-white spots on the inner cheek mucosa, usually seen during the prodromal phase (fever with cough, coryza, and conjunctivitis) before the rash appears. Their presence almost uniquely points to measles, so when you see them in the appropriate clinical context, they strongly confirm the diagnosis. While not every patient will have them, and their absence doesn’t rule out measles, their appearance is a highly diagnostic sign that differentiates measles from other viral rashes.